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CBD, CBDA and the TRPV1 Receptor

Science generally doesn’t like it when when a molecule does ten different things at once. CBD and CBDa do exactly that (probably a lot more than ten) which is why we hear so much debate and discussion about what exactly CBD and CBDa do when we consume them.

It is further confounding to researches that, although CBD and CBDa are definitely cannabinoids, they do not interact directly with the known cannabinoid receptors (CB1 and CB2). One receptor that we know for sure that CBD and CBDa are able to plug directly into is the TRPV1 receptor, the same place hot peppers plug in. When activated, this receptor can tell us that the pepper is “hot,” it can modulate inflammatory responses, plays an important roll in the absorption/metabolization of calcium, and interacts with many many other important bodily functions. TRPV1 can be stimulated by both exogenous and endogenous cannabinoids, extreme body temperature, low PH in the body, etc. 

TRPV1 is involved in our overall perception of pain and may play a key role in the relief some people experience after taking CBD or CBDa. It is important to recognize that TRPV1 does develop a tolerance to things like spicy foods. Much of the current research into CBD and CBDa does not show our bodies desensitizing to them over time, though we have definitely met some CBD and CBDa consumers that found they needed to take more over time to get the same results. This is one more reason it is so important to start low, and go slow when finding what amount of CBD or CBDa works best for you. Some CBD providers have hypothesized that tolerance is much more likely when someone starts by taking more than they need, which may cause a down regulation of key receptors such as TRPV1. 

Before taking anything new, always talk with your healthcare practitioner, take the time to learn about basic dosing protocols and feel free to reach out to Circle Labs if you have any questions. If we can’t answer your questions, we will definitely point you towards someone who can. 

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